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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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The immune response levels and protective evaluation induced by different doses <t>of</t> <t>CpG-ODN</t> adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).
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Image Search Results


The immune response levels and protective evaluation induced by different doses of CpG-ODN adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).

Journal: Vaccines

Article Title: Comparative Evaluation of Mucosal Adjuvants for Intranasal Immunization with a Recombinant RSV Prefusion F Protein

doi: 10.3390/vaccines14020186

Figure Lengend Snippet: The immune response levels and protective evaluation induced by different doses of CpG-ODN adjuvant in mice: ( A ) Experimental groups and immunization regimen; ( B ) Serum antigen-specific IgG levels after immunization; ( C ) Serum neutralizing antibody titers after immunization; ( D ) Antigen-specific IgA levels in nasal lavage fluid after challenge; ( E ) Body weight changes after challenge; ( F ) Ct values for lung viral load after challenge; ( G ) Total lung pathology score after challenge; ( H ) Antigen-specific IgA in lung homogenates after challenge; (* p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.0001; ns, not significant).

Article Snippet: Type C CpG-ODN (ODN 2395, VacciGradeTM), PMA plus ionomycin, and mouse lymphocyte separation medium were purchased from Dakewe Biotech Co., Ltd.

Techniques: Adjuvant